About Us

The research in our laboratory is focused on four different areas:

  • The development of novel and improved mass spectrometric and proteomic methods for the analysis of complex protein mixtures and the detailed characterization of proteins within these mixtures, including the analysis of post-translational protein modifications and the quantitation of protein abundances.
  • Development of instrument platforms for the detection and identification of disease-markers with special emphasis on pediatric diseases.
  • The use of mass spectrometry to identify mechanisms of cell cycle control during neurogenesis.
  • Development and applications of strategies to solve systems biological questions and problems at the proteome level.

    • Dr. Judith Steen, Core Director

    Dr. Steen is a neurobiologist with broad expertise in mass spectrometry, genetics, cell biology and proteomics; she is an assistant professor of Neurology at Harvard Medical School and is a member of the Neurobiology Program at Children’s Hospital. She was trained at the University of Southern Denmark by Peter Roepstorff (an early founder of mass spectrometry-based proteomics) and Dr. Marc Kirchner in the Department of Systems Biology. One of Dr. Steen’s major research interests is the development of MS-based proteomic technology as driven by biological needs - she is currently focused on developing and applying quantitative methods to study neurodegeneration and regeneration.

    Core Technician-Mr. John F.K. Sauld

    Mr. Sauld studied at the Roxbury Community College and also graduated from the Year Up program which provided him with IT training. Mr. Sauld performs both wet lab work and data analysis for the proteomics core. He is responsible for the day to day operations in the facility.