Biostatistics Support
The Research Computing Division is the primary source of online statistical tools for CHB investigators. Statistical application software including SAS, SPSS, SPSS entry builder and STATA are available to all researchers through the hospital intranet. These programs are continuously updated for new versions, and are compatible with a range of database platforms available to the researchers.
Software available through Research Computing for genetic sequence analysis includes the Accelrys GCG gene analysis software and related MacVector analysis and Sequencher packages. In addition, the Hospital research website maintains the latest version of Vector NTI (sequence creation, mapping, analysis, annotation, illustration and management), AlignX (multiple sequence alignment of proteins and DNAs), ContigExpress ( DNA sequence assembly), BioAnnotator ( functional annotation of proteins and DNAs), and GenomBench (analysis and annotation of reference genomic DNA sequences).
Clinical researchers can also request biostatistical consults from the Clinical Research Program by completing and submitting their online request form ( http://crp-apps.chboston.org/crp.intake/public/IntakeRequest.aspx ) The CRP staff provide consultative services regarding clinical protocols and grant proposal development, study design, sample size and power calculations, statistical analysis, randomization approaches, case report form and survey design, data management and systems design, data interpretation, study implementation (development of case report forms, manuals of operations, study database, and data entry as well as reports to monitor study data collection status and accuracy and completeness of the data) and data analysis.
In addition to these centralized services, more specialized statistical support is offered within several of our Cores. The Cellular Neuroscience Core assists researchers with statistical analysis of histopathological material and stereology. The Molecular Genetics Core provides customized assistance and experimental design planning to researchers using gene arrays, as well as data interpretation and statistical analysis. The Proteomics Core assists individual researchers with group design and statistical analysis.
Graphics Services
The Countway Library of Medicine at Harvard Medical School provides assistance to Harvard faculty in the area of digital imaging. The Research Imaging Consortium, headed by Ms. Beth Beighlie, continuously identifies trends in digital imaging and offers state-of-the-art assistance to Harvard faculty in the creation of basic medical illustrations and photographic images for use in medical and scientific publications as well as presentations, lectures and seminars. This consortium has launched an ongoing imaging skills seminar series which is available to all IDDRC investigators. Special seminars can also be organized according to the needs of our PIs.
How to get help
Research Imaging Solutions email address: RIS@hms.harvard.edu
Most graphics questions can be answered by going to http://it.med.harvard.edu/ris
Contact Beth Beighlie at 432-2323. Beth is available to come to your lab or office to troubleshoot your problematic images, presentations and publication graphics. Information on equipment, applications and resources for digital imaging can be found at http://it.med.harvard.edu/ris